Abstract
A series of 4-[2-(aminomethyl)phenyl]-1-[bis(2-chlorophenyl)methyl]-4-hydroxypiperidine analogs has been identified as nociceptin receptor ligands. These compounds display high affinity and functional activity at the nociceptin receptor. The synthesis and structure-activity relationships at the C-4 phenyl and N-1 positions are described and the antitussive activity of a selected compound is reported.
MeSH terms
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Animals
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Antitussive Agents / chemical synthesis
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Antitussive Agents / chemistry*
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Antitussive Agents / pharmacology*
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CHO Cells
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Cricetinae
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Cricetulus
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Guinea Pigs
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Humans
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Ligands
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Nociceptin Receptor
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Piperidines / chemical synthesis
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Piperidines / chemistry*
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Piperidines / pharmacology*
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Receptors, Opioid / agonists*
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Structure-Activity Relationship
Substances
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Antitussive Agents
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Ligands
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Piperidines
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Receptors, Opioid
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Nociceptin Receptor